Serial Do Alone In The Dark 2008
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the main search terms were applied in different combinations to the pubmed and cinahl databases. terms were applied individually and in various combinations including (i) “cerebral palsy”, “spastic diplegia”, “lower limb” and “serial casting” (see additional file 1 ); (ii) “cerebral palsy”, “spastic diplegia”, “lower limb” and “serial casting” (see additional file 2 ); and (iii) “cerebral palsy”, “spastic diplegia”, “lower limb” and “serial casting” (see additional file 3 ). the search terms were applied to both abstracts and titles to retrieve relevant studies for inclusion in the review. the three databases were searched from inception to january 2010. inclusion criteria were applied to titles and abstracts using a two-stage assessment process. if studies were found to be potentially relevant after title and abstract review, the full-text of articles was retrieved and assessed for inclusion. initially, a two-stage assessment process was used. the first stage of the assessment process included four independent reviewers (pb, rm, cb, pm). the second stage of the assessment process involved a consensus meeting and discussion among the reviewers to determine if the study could be included in the review. this process was used to reduce the potential for errors and increase the quality of the review. following the inclusion process, a review of the selected studies was undertaken to determine the best fit for inclusion in the review. all references were imported into endnote x3 software (thomson reuters, carlsbad, ca) and duplicates were removed.
of the 25 articles included in this review, six studies used btx-a [ 11, 16, 22, 28, 29, 31 ] and one study used btx-a and serial casting with the intention of increasing prom [ 50 ]. three studies compared serial casting with btx-a [ 28, 31, 50 ], of which, one study used two doses of btx-a [ 31 ]. five studies did not utilise any pharmacological intervention [ 15, 22, 29, 44, 56 ].
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