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Most popular software: Sage Pastel Partner, Pastel Xpress Version 18, Sage 50 Accounting, Sage 50 Accounting Partner, Pastel Xpress 11.0, Pastel… 11.0.0 Star Acct Software 2017Â .
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Noncompliance is a leading cause of medication error, which results in clinically significant outcomes, including death. A novel technique was developed to predict the bolus retention of oral solid dosage forms in the gastrointestinal tract. This method is based on the amount of pharmaceutical material eluted from a small piece of material from a tablet, capsule, or granule that is swallowed in a fixed time window. Test tablets with a drug payload ranging from 0% to 80% were directly compared with isotonically disintegrated tablets of identical formulation, and the numerical relationship between the amount of drug eluted from the test tablets and the drug payload was established. The tablet and granule were then pressed into pellets, which were then swallowed in a fixed time window to simulate patient behavior. The method was validated against data from seven independent studies on an oral solid dosage form with a known drug payload. Compared with the known drug payload, the test disintegrating tablet showed an excellent correlation to the isotonically disintegrated tablets. When applied to a fixed time window (up to 3 min), the novel method showed that the retention of a solid
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