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This book work is from the library of medicine and general medicine which is included in the medical holdings of the. Bibliotheca medicinae see details: http:www.polonmed.elca.plProtective effects of granulocyte-macrophage colony-stimulating factor on hyperoxic lung injury in rats.
Because a previous study demonstrated the inability of granulocyte-macrophage colony-stimulating factor (GM-CSF) to protect against hyperoxic lung injury, this study examined the potential role of GM-CSF in preventing lung injury induced by hyperoxia. On Day 0, rats were divided into three groups: control group, exposed to hyperoxia (90%) for 4 days; GM-CSF group, exposed to hyperoxia + GM-CSF, and GM-CSF alone group. On Day 5, the animals were killed, and the lungs were harvested. Hyperoxic lung injury was assessed by measurements of the wet-to-dry weight ratio, cell proliferation, DNA oxidation, and airway responsiveness. The wet-to-dry weight ratio, DNA oxidation, and airway responsiveness were significantly increased in the hyperoxia group compared with the control group. There was a significantly lower wet-to-dry weight ratio in the hyperoxia + GM-CSF group and GM-CSF alone group compared with the hyperoxia group. DNA oxidation was significantly decreased in the hyperoxia + GM-CSF group and GM-CSF alone group compared with the hyperoxia group. On Day 5, the airway responsiveness was significantly increased in the hyperoxia group compared with the control group. There was a significantly decreased airway responsiveness in the hyperoxia + GM-CSF group and GM-CSF alone group compared with the hyperoxia group. The results from this study demonstrate that administration of GM-CSF is protective of lung injury induced by hyperoxia.Q:
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Mcgraw Hill US History 2 Edition
Mcgraw Hill US History 2 Edition
Mcgraw Hill US History 2 Edition
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The Library and Culture of the Middle Ages. Oxford: Blackwell Publishers. ISBN. Foundations of Nineteenth-Century Chemistry: The Proceedings of the 4th International Congress of Chemists,. Haldane: The Library of Chemistry of the Royal College of Science, McGraw-Hill.
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