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Apr 13, 2012
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Discussion
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Recently, PLBMs have been under intensive investigation. Their functions are not limited to the basic role of preserving the stem cells that will have a promising application in regenerative medicine. Among them are cellular senescence, post-replication repair, chromatid breaks repair and other stem cell functions.[@b38-tcrm-13-1343] Many of these functionalities appear to have a clinical impact. According to some studies, older donors have more PLBMs than younger donors.[@b39-tcrm-13-1343],[@b40-tcrm-13-1343]
All over the world, the rate of ROS increases over time and leads to cellular damage. In this context, a promising way to avoid this damage is to supplement an antioxidant. One of the most important and potent antioxidants is vitamin C. Nowadays, most of the PLBMs are recruited at S phase of cell cycle. The main event in this phase is the synthesis of DNA. The action of DNA synthesis is driven by the complex formed between the DNA replication machinery and nucleotides.[@b41-tcrm-13-1343] ROS level increase, to some extent, may cause PLBMs mis-incorporation. This reaction leads to the formation of 8-oxodG.
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