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CD137, also known as OX40, is a member of the tumor necrosis factor receptor superfamily. CD137 is a 43 kDa type-1 glycoprotein that is expressed on activated T lymphocytes. Upon CD137 ligation, CD137 recruits members of the NF-κB family, which bind to and activate the transcriptional factors NF-κB, activator protein-1 (AP-1), and nuclear factor of activated T cells (NF-AT) into the nucleus. CD137 is involved in several immune cell functions including proliferation, survival, activation, and differentiation. Specifically, CD137 ligation of CD137 on T cells results in T cell proliferation. OX40 ligation of OX40 on T cells, T cell lines, and human T cell clones induces IL-2, IL-4, IL-5, IL-6, and IFN-γ secretion as well as induces T cell proliferation. Moreover, CD137 ligation induces many gene promoters, including IL-2, IL-4, IL-5, and IFN-γ.Q:
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