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The clinical application of somatostatin analogs in acromegaly has been almost three decades old. A general explanation for the positive outcome of these analogs was that in certain compartments, other than the anterior pituitary, somatostatin is expressed. Anterior pituitary cells, however, produce proteins different from somatostatin. Most importantly, the pituitary expresses high levels of growth hormone (GH) receptors (GHR). Somatostatin analogs enter cells via the same mechanism as growth hormone-releasing factor (GRF) and regulate the concentration of this growth factor. This classical concept is reexamined, and so is the putative presence of somatostatin receptors in nonpituitary cells. This review was conducted to summarize the literature on the presence of somatostatin receptors in nonpituitary cells and to assess to what extent the presence of these receptors explains the positive clinical effects of somatostatin analogs. Somatostatin (SST)-expressing cells, in situ hybridization, and electron-microscopic autoradiography as well as immunocytochemistry are reviewed. The presence of SST receptors is confirmed in the spleen, lymph nodes, peripheral nerves, placenta, and many other tissues, including the pituitary gland. Because no ligand has been identified for this receptor, their function is not clear. These receptors may be transporters, are in close contact with their binding site, or are autoactivated. The existence of such receptors in tumors raised the possibility of their use as growth factor-receptor blockers. We are planning studies on growth hormone and their analogs using cell systems and in vitro tissue culture methods.Methotrexate-associated rheumatic disease: systematic review and meta-analysis of the incidence, management and outcomes of seronegative spondyloarthropathies.
Methotrexate (MTX) is widely used in the treatment of inflammatory arthritis, but concerns have been expressed over its use in inflammatory arthritis associated with seronegative spondyloarthropathies. This study was performed to identify if there is a true association
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Manuale Di Tecniche E Procedure Infermieristiche Di Taylorzip
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