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Previous.News: A third Medicaid drug scandle has emerged.

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A third drug maker has been hit with a big fine by U.S. regulators over its marketing practices.

A federal investigation of GlaxoSmithKline’s failure to adequately report problems with a diabetes drug uncovered a scandal that has already cost the company a fine of about $40 million, the U.S. Attorney’s Office in Boston said Thursday.

GSK also faces three lawsuits in which the shareholders of Indianapolis-based Cardiopharma allege that they were duped into selling a drug called Zetia at inflated prices.

A spokeswoman for GlaxoSmithKline said it “believes the issues identified by the FDA are not related to the quality or efficacy of Zetia. Rather, the safety concerns appear to be related to the packaging of the drug.”

In the first two cases, shareholders of Chicago-based Cardiopharma are alleging that the drug was paid too much for by GSK. Both suits were filed this year in U.S. District Court in Indiana.

In the third case, shareholders of Cardiopharma sued GlaxoSmithKline and other defendants, claiming that they were duped by GSK into selling Zetia, which is prescribed to treat high cholesterol. They allege that the price of the drug was inflated because they were promised that the drug would be received by Cardiopharma and, even though it was not, Cardiopharma paid for it anyway.

Cardiopharma’s stock has been declining as a result of investors’ fears over the reimbursement problems. The Securities and Exchange Commission is suing the drugmaker over the same allegations.

Cardiopharma has sold the drug to about 23,000 customers, such as hospitals, universities and doctors, nationwide, and its business has declined more than 80 percent since the start of 2007. The company’s $35 million in sales last year were down from $112 million in 2006.

The drug maker cited patient safety concerns as the reason for withdrawing the drug in March 2010, and the Food and Drug Administration agreed with that decision.

GSK’s fine stems from an investigation into its 2006 marketing of Zetia, a Ziacin tablet, for high cholesterol, which the company discovered was too large. The company also found that the dosage of Zetia was not protected and should have been

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