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Autoantibodies to neural cell adhesion molecule (NCAM) have been used as markers for autoimmune neuropathies, although their specificity as autoantibodies is uncertain. We now report that, in addition to autoantibodies to NCAM, serum from a number of patients contains antibodies to L1 protein, an integral membrane protein of cells of the nervous system. The antibodies are not identical to those against NCAM. Autoantibodies to L1 protein were detected in patients with demyelinating polyneuropathies, where NCAM autoantibodies are rare, and in paraproteinemic neuropathy. On a panel of 112 antigens including L1, antibodies of IgM isotype were detected in two of 28 patients with paraproteinemic neuropathy, seven of 50 with neuropathy associated with monoclonal gammopathy of undetermined significance and one of 14 patients with de- and remyelinating neuropathy. The antibody reacted with a protein in a 68-kilodalton species in immunoblots of L1 immunoprecipitated from rat brain tissue. The antigen was also expressed in mouse brain and livers of human fetal liver and hepatocytes. The relationship of these autoantibodies to a neuropathological condition and their pathogenic role remain to be determined.Chow, who died from cancer at age 36, left behind a life of film, television and musical success. Her acting career included stints on “Dawson’s Creek,” “Spin City” and �
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