Download Financial Times Europe 25 February 2020 (.PDF)
News, analysis and commentary from the Financial Times, the world’s leading global business publication. The Financial Times is the leading global business publication.
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The in vitro effects of the beta-adrenoceptor agonists clenbuterol and isoproterenol on guanosine triphosphatase (GTPase) activity in the pineal gland were investigated. Both compounds were found to significantly increase the hydrolytic activity of GTPase. The increase was reflected in an increase in guanosine diphosphate (GDP) production from GTP and a concomitant decrease in guanosine 5′-triphosphate (GTP) hydrolysis. The effect was concentration dependent. Activation of the melatonin pathway by these agonists was also investigated. Isoproterenol and clenbuterol increased the rate of melatonin production by the pineal, and this effect was abolished by indomethacin and pertussis toxin. These results indicate that beta-adrenoceptor stimulation by clenbuterol and isoproterenol increase pineal melatonin production by a guanosine triphosphate (GTP)- and phosphatidyl inositol 4,5-bisphosphate (PIP2)-dependent mechanism.Can changing friends and social circles improve health outcomes?
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